Health glossary · Women's Health

Lesion

LEE-zhunnoun

A general medical term for any area of abnormal tissue in the body, which may be benign or concerning.

A lesion is a broad medical term for any region of tissue that has been damaged, changed, or is otherwise abnormal compared to the surrounding tissue. Lesions can be caused by injury, infection, inflammation, or abnormal cell growth — including cancer. The word itself carries no implication about severity; a lesion may be entirely benign or require further investigation.

Part of speechnoun
PronunciationLEE-zhun
OriginLatin laesio, from laedere (to hurt, to damage). The term entered medical use to describe any area of abnormal tissue, whether due to injury, disease, or other cause.

What is lesion?

If your doctor or a radiology report mentions a 'lesion,' you may be left wondering what that actually means for you. The term is deliberately broad — it simply describes any area of tissue that looks or behaves differently from the surrounding normal tissue. A lesion can be a bruise, a scar, an area of inflammation, a cyst, a benign growth, or an area of cancer. The word alone tells you very little about severity.

In breast imaging, a lesion might be an area detected on a mammogram, ultrasound, or MRI that requires a closer look. It could be a cyst (a fluid-filled sac, usually benign), a fibroadenoma (a common benign lump), an area of calcifications, or something that warrants a biopsy to determine its nature. In multiple sclerosis, lesions refer to areas of damage to the myelin sheath in the brain or spinal cord that are visible on MRI. In dermatology, lesions include any abnormal skin spot. The context in which the word is used shapes what it actually means.

When a medical provider tells you a lesion has been found, the natural next question is: what type of lesion is it, what caused it, and what — if anything — needs to happen next? Many lesions require no treatment at all, some need monitoring over time, and others require biopsy or further imaging to characterize them fully. The description of a lesion — its size, shape, borders, internal features, and imaging characteristics — guides how the medical team proceeds.

Why it matters

Hearing the word 'lesion' in a medical report or during a conversation with your doctor can trigger immediate worry, but understanding that it is a neutral descriptor — not a diagnosis — can help you stay grounded while you gather more information. The important follow-up is always: what kind of lesion, and what does my provider recommend doing about it?

In a breast health context, many lesions detected on imaging turn out to be benign on further evaluation. The purpose of diagnostic imaging and biopsy is to characterize lesions accurately so that genuinely concerning findings get appropriate attention and truly benign ones do not lead to unnecessary intervention. If you have received a report mentioning a lesion and are awaiting clarification, writing down your questions before your next appointment can help you make the most of that conversation.

Related terms

Related articles